Codeinum cod.

An Alkaloid from Opium

Trembling of whole body. Involuntary twitching of muscles of arms and lower limbs. Itching, with feeling of warmth, numbness and prickling. Diabetes.

Pain from occiput to back of neck. Skin of face and scalp sore after neuralgia.

Involuntary twitching of lids (Agar).

Spasmodic pain at pit of stomach. Eructations. Great thirst, with desire for bitter substances.

Short and irritating cough; worse, at night. Copious, purulent expectoration. Night cough of phthisis.

Compare: Opium; Agaricus; Hyoscy; Ammon brom.

One-quarter of a grain doses to third trituration.

An Alkaloid of Opium. C 18 H 21 NO 3 .

Blepharospasm . Chorea. Cough. Diabetes. Eczema. Gastralgia. Numbness . Pruritus. Restlessness. Spasmodic twitchings. Vomiting of pregnancy.

Codein possesses many of the properties of opium, from which it is derived, but it has characters sufficiently distinctive to entitle it to a separate description. Codein seems to possess in great degree the exhilarating properties some persons experience on taking opium, though it is not without strong soporific effects as well. There are many disorders of sensation, notably troublesome itching. The characteristic here is "Itching with warmth." "Itching and heat of face and head." "A sensation of agreeable warmth" is another characteristic symptom. Convulsive twitchings of muscles and limbs, and especially of orbital muscles, are very marked. Twitchings prevent sleep at night. Numbness and prickling. Codein has in many cases controlled diabetes. Headache is < in morning; restlessness and cough < at night. Symptoms in general are < by motion and > by rest.

Compare: Opium in sickness, pains in stomach and region of solar plexus, constipation, sexual excitement. Agar. (twitching of eyelids; Ars. (pains in legs, nightly restlessness); Hyo. (twitching of eyelids after reading); Lach. (sensitiveness of surface); Rhus, Sul., Sul. ac. (trembling); Culex (vertigo on blowing nose).

Fatigue and excessive mental excitement = headache.

Great exhilaration of spirits. — Depression with desire to sleep, frightful dreams and dull headache on awaking. — Increased or diminished power of fixing attention or applying mind. — Bewildered on waking. — Confusion.

Dizziness on blowing nose. — When closing eyes objects appear to turn round. — Dull headache in morning, gradually diminishes towards noon when it disappears. — Dull headache soon after rising, < l. side, lasting about two hours. — Dull headache with dry lips and constant desire to moisten them. — Headache from fatigue and excessive mental excitement.

Involuntary twitching of l. eyelid, sometimes > by rubbing. — Involuntary twitching of both eyelids whenever he attempted to read or write. — Pupils contracted. — Sudden failure of vision. — On blowing nose sparks before eyes.

Mucous discharge with irritation of the Schneiderian membrane. — Entire loss of smell for several days.

Mouth dry. — Unable to articulate.

Strong pulsations in both carotids. — Tickling sensation in throat, in afternoons and evenings.

Great thirst with a particular desire for bitter substances. — Empty eructations with acute pains in stomach. — Nausea and vomiting; sometimes preceded by an agreeable glow at epigastrium. — Tenderness in stomach with violent pulsations of heart and carotids. — Violent spasmodic pain at pit of stomach (solar plexus).

Constipation, with tenderness of bowels, esp. transverse and descending colon, and some flatulence.

Semi-paralysis of bladder. — Quantity of urine increased and saccharine.

Sexual excitement during the night, leading to pollutions.

Tickling in larynx which causes a cough. — Short, irritating cough < during night. — Troublesome cough with copious mucous, and sometimes purulent, expectoration; with nervous excitability. — Night cough of phthisis. — On inspiration, pain in r. lung; pain below scapula; stitching pains in l. lung.

Uneasy feeling about heart. — Fluttering and oppression with great desire to walk in open air. — Painful pulsation when attempting to study or write. — Violent pulsations of heart and carotids.

Neuralgic pains from occiput to back of neck. — Convulsions in muscles of back. — Sharp pains extending from stomach and chest through to back, between shoulders, < on r. side.

Paralytic weakness in arms and legs. — Spasmodic twitches in arms and legs. — Numbness of hands and feet; prickling and numb sensation in various parts of the body.

Pains in deltoids on moving arms. — Jerking pain in arm. — Pulsating pain in l. upper arm.

In lower limbs involuntary twitchings; spasmodic jerkings; neuralgia and rheumatic pains. — Paralytic affections with extreme restlessness.

Extreme restlessness. — Trembling of whole body. — Marked sensitiveness of surface. — Choreic movements. — Symptoms are periodic, paroxysmal; at times sudden.

Itchy; prickling. — Eczematous eruption with troublesome itching. — Itching with feeling of warmth.

Sleepy and drowsy. — Twitchings in sleep. — Cough disturbing sleep. — Frightful dreams.

An alkaloid of Opium. C 18 H 21 NO 3 .
Provings by E. E. Marcy and others (See Encyclopædia, vol. 3 ).
"Discovered in 1832 by Robiquet in the muriate of morphia, prepared according to the process of Gregory. It exists in opium, combined with meconic acid, and is extracted along with morphia in the preparation of muriate of morphia."
The provings evolve many symptoms similar to those we find in the provings of morphia.
CLINICAL AUTHORITIES.
- Twitching of eyelids , Marcy, Hale's Therap., p. 185 ; Soreness of skin of face and scalp after neuralgia , E. E. Marcy, N. A. J. H., vol. 5, p. 414 ; Spasmodic pain in stomach , Marcy, N. A. J. H., vol. 5, p. 419 ; Diabetes , Pavy, B. J. H., vol. 29, p. 818 ; Night cough of consumptives , Hale's Therap., p. 185 ; Sudden twitchings during sleep , E. E. Marcy, N. A. J. H., vol. 5, p. 416 ; Disturbed sleep from frightful dreams , E. E. Marcy, N. A. J. H., vol. 5, p. 416.

Great mental exhilaration.
Depression of spirits with dull headache.
Inability to apply the mind.
Lascivious thoughts.

Confusion and heat of head.

Heat in head.
Dull headache in morning, which gradually diminishes until noon, when it disappears.
Dull headache soon after getting up in morning, < on l. side, and lasting about two hours.
Headache from fatigue and excessive mental excitement.

Weakness of vision.
Involuntary twitching of left eyelid, sometimes > by rubbing.
Involuntary twitching of both eyelids, whenever he attempted to read or write.

Entire loss of smell.

Painful soreness of skin of face and scalp, which remained after a severe attack of neuralgia.

Lips dry and parched, constant inclination to moisten skin.

Dryness of mouth.

Tickling sensation in throat, in afternoon and evening.

Great thirst, with a particular desire for bitter substances.

Empty eructations, with acute pains in stomach.
Nausea and vomiting.

Tenderness in stomach, with violent pulsations of heart and carotids.
Violent spasmodic pain at pit of stomach.
Gastralgia.
(OBS :) Neuralgia of stomach and solar plexus.
Affections of stomach or abdomen, dependent on disorder of solar plexus of great sympathetic.

Extreme tenderness of lower part of abdomen.
Dull pain throughout entire abdomen.
Gastric and abdominal neuralgia.

Constipation with tenderness of bowels, especially in transverse and descending colon.

Increased secretion of urine, it being lighter in color.
Semi-paralysis of bladder.
She passed five pints of urine daily, specific gravity 10.40 and sugar to the extent of 32.72 grains ; < from anxiety and overwork.
The urine previously saccharine contained no trace of sugar.

Sexual excitement during night leading to nocturnal pollutions.

Nausea and vomiting during pregnancy.

Short, irritating cough < during night.
Troublesome cough, with copious mucous and sometimes purulent expectoration.
Obstinate cough with expectoration and nervous excitability.
Night cough of phthisical patients.

Fulness and oppression of chest.
Sharp pain in right lung on inspiration.
Stitching pains in left lung on breathing.
Severe pain in shoulder and chest on motion.

Sympathetic palpitation of heart and irregular action from derangement of ganglionic system.
Violent palpitation of heart and carotids.
Painful pulsations of heart on attempting to study or write.
Drawing pain around heart, which beats loud and full.

Convulsions in muscles of neck.
Convulsive movements of muscles of back and neck.
Neuralgic pains from occiput to back of neck.
Painful pulsations in left side of neck.
Sharp pains extending from stomach and chest through to back, between shoulders, < on right side.
Acute pains in region of kidneys.

Spasmodic twitches in arms.
On moving arm, severe pain in deltoid muscles.
Pulsating pain in left upper arm.
Numbness of hands and arms.

Sensation and power of motion impaired.
Involuntary twitchings of lower limbs.
Painful, spasmodic jerking of legs.
Neuralgic pains in thighs and legs, and subacute rheumatic pains in knee and ankle joints.
Sudden pain in knee joints, making walking impossible for a few minutes.
Paralytic affections of lower extremities, with extreme restlessness, constant desire to change position, and inability to sleep.

Spasmodic twitching of upper and lower extremities.

Motion : severe pain in shoulder and chest.
On moving arm : severe pain in deltoid muscles.

Extreme restlessness.
Trembling of whole body.
Morbid sensitiveness of surface in nervous and hysterical females.
Frequent paroxysms of involuntary twitchings of muscles of all parts of body, indigestion and various manifestations of morbid excitability of nervous system in consequence of chronic ovaritis and suppressed menstruation.
Chorea ; sleep constantly disturbed ; unusual tendency to involuntary twitching of muscles of different parts of body.

Sleepiness, drowsy feeling.
Sudden twitchings during sleep, so violent as to wake up the sleeper in affright. θ Chorea.
Disturbed sleep from frightful dreams, causing patients to wake in morning exhausted and unrefreshed.
Sleep constantly disturbed by severe night cough. θ Phthisis.

In morning : dull headache, which gradually diminishes until noon, when it disappears ; dull headache soon after getting up, < on left side, and lasting about two hours ; awakes exhausted and unrefreshed on account of disturbed sleep.
In afternoon : tickling in throat.
In evening : tickling in throat.
During night : sexual excitement leading to nocturnal pollutions ; short, irritating cough worse.
Night cough of phthisical patients.

Sudden : pain in knee joints ; twitchings during sleep.
Spasmodic : twitching of left eyelid ; twitches in arms ; jerking of legs ; twitching of upper and lower extremities.
Frequent : paroxysms of involuntary twitching of muscles of all parts of body.
For a few minutes : walking impossible on account of sudden pain in knee joints.
Constant : inclination to moisten skin ; desire to change position ; disturbance of sleep from chorea ; disturbance of sleep by night cough.
Lasting about two hours : dull headache < on left side, soon after getting up in morning.
Dull headache in morning, which gradually diminishes until noon, when it disappears.

Right : sharp pain in lung on inspiration ; sharp pains from stomach and chest through to back, between shoulders, < on side.
Left : dull headache < on side ; involuntary twitching of eyelid ; stitching pains in lung on breathing ; painful pulsations in side of neck ; pulsating pain in upper arm.

Pains : in stomach ; in shoulder and chest ; in deltoid muscles ; in knee joints.
Stitching pains : in left lung on breathing.
Painful spasmodic jerking : of legs.
Drawing pains : around heart.
Painful soreness : of skin of face and scalp, after neuralgia.
Sharp pain : in right lung on inspiration ; from stomach and chest through to back, between shoulders, < on right side.
Acute pains : in region of kidneys ; in stomach.
Neuralgic pains : from occiput to back of neck ; in thighs and legs ; of stomach and solar plexus.
Subacute rheumatic pains : in knee and ankle joints.
Spasmodic pain : at pit of stomach.
Pulsating pain : in left upper arm.
Painful pulsations : of heart on attempting to study or write ; in left side of neck.
Prickling : of skin.
Dull pain : throughout entire abdomen.
Dull : headache.
Oppression : of chest.
Fulness : of chest.
Itching : of skin over whole body ; of eczema and porrigo.
Tenderness : in stomach ; of bowels, especially in transverse and descending colon.
Tickling : in throat.
Numbness : of hands and arms.
Dryness : of lips ; of mouth.
Heat : of head.

Sensation of general warmth with itching of skin, over whole body.

Rubbing : involuntary twitching of left eyelid, sometimes > by.

Itching of skin over whole body.
Troublesome itching of eczema and porrigo.
Prickling of skin.

Woman, æt. 68 ; diabetes.

Codeineum cured gastralgia, which had withstood all other remedies, Bellad . included.
Codeinum relieved cough and sleeplessness in phthisical patients after failure of Hyos., Ipecac . and Conium .
Compare : Agar . (twitching of eyelids) ; Arsen . (pains in legs and nightly restlessness) ; Hyos . (twitching of eyelids after reading) ; Laches . (superficial sensitiveness) ; Rhus tox . (chorea, nightly restlessness, pains in legs) ; Sulphur (spasmodic twitching of legs) ; Sulph. ac . (trembling of whole body).

Pure codeia (one of the alkaloids of Opium) is prepared for use by trituration.

This alkaloid similar in a general way to Morphia, seems to possess convulsant properties in a higher degree than the other alkaloids of Opium.

▶ Trembling of whole body. ▶ Convulsive motions; of different parts; of muscles of chest, neck, arms and legs, then (in one case) soreness of the parts and weakness. ▶ Inflammation if placed in contact with the cellular tissues. ▶ Circulation and respiration rapid, then depressed. ▶ Prickling in various parts, with numbness. ▶ Restlessness. ▶ Constant inclination to sit and close eyes. ▶ Weakness. ▶ Nervous sensibility increased, then depressed. ▶ Heaviness. ▶ Sensation and power of motion impaired. ▶ Paralysis, agg. lower limbs; state of mixed P. and spasm, both tonic and clonic.

Delirious at night. ▶ Bewildered. ▶ Excited as after spirituous drinks. ▶ Gay. ▶ Exhilarated. ▶ Depressed spirits and headache; D., with sleepiness, frightful dreams, and on waking in morning dull headache. ▶ Tranquil. ▶ Listless. ▶ Increased capacity. ▶ Stupor; in afternoon and evening, with disinclination for exertion. ▶ Sluggish association of ideas. ▶ Inability to concentrate mind; or to remain quiet in the house.

▶ Aching in morning after rising, agg. left side; in morning, amel. noon; with dry lips. ▶ Confusion; and heat. ▶ Strong pulsations, and on carotids. ▶ Vertigo; in afternoon; on blowing nose; on blowing nose, with sparks before eyes wherever he looks; as if the room went round with him; objects appear to turn around on closing eyes. ▶ Pressure in temporal and frontal regions. ▶ Pulsating pain in right temple in afternoon. ▶ Neuralgic pain in occiput extending to nape. ▶ Itching of head extending over whole body.

Eyes injected; sclerotic injected. ▶ Eyes glassy and immovable. ▶ Burning in eyes, agg. left. ▶ Pupils dilated; contracted. ▶ Vision weak; did not see the letter distinctly on beginning to write; failed suddenly. ▶ V. of floating sparks on stooping. ▶ Stoppage of ears. ▶ Ringing in ears.

Twitching of eyelids (Agar., Croc.).

Diabetes.

Dry, teasing cough, with phthisis.

Nasal discharge, with irritation of schneideran membrane. ▶ Los of smell. ▶ Face animated, rosy and gay, or dull and stupid. ▶ Terrified look. ▶ Pallor. ▶ Lips dry.

Dryness of anterior part of tongue and hard palate; of mouth, with thirst for beer. ▶ Inability to speak. ▶ Salivation. ▶ Tickling in throat in afternoon and evening.

Loss of appetite. ▶ Thirst; with desire for bitter substances. ▶ Eructations. ▶ Nausea. ▶ Violent retching on attempting to move. ▶ Vomiting. ▶ Pain; paroxysms of neuralgic, and in abdomen; acute, and in chest, extending through to back, between shoulders, agg. right side of spine. ▶ Tenderness, with violent pulsations of heart and arteries.

A. distended with flatus. ▶ Peristaltic action diminished. ▶ Pain in transverse colon, amel. gentle pressure; P. in A., with pulsations and rapid circulation and respiration. ▶ Tenderness of A. in morning extending to epigastrium and lungs; of hypogastrium in morning. ▶ Uncommon sense of tonicity in A. ▶ Purging. ▶ Constipation, tenderness of bowels, agg. transverse and descending colon, and flatulence.

Diminished power of retention of urine and semi-paralysis of neck of bladder. ▶ Urine increased and light-colored, then scanty. ▶ Lascivious thoughts, causing frequent erections, day and night; excitement at night, with pollutions. ▶ Sexual power increased, then diminished.

Tickling in larynx causing cough. ▶ Voice reduced to a whisper. ▶ Cough in morning, with soreness and sticking; short and irritating C., agg. night; C., with copious mucous and sometimes purulent expectoration. ▶ Sticking in left lung on breathing. ▶ Sharp pain in right ling on inspiration. ▶ Pain in chest and shoulder on motion. ▶ Sore feeling in sternal region. ▶ Fulness and oppression of chest. ▶ Drooping sensation below left clavicle.

Drawing pain around H., with loud and full beats of it, causing uneasiness. ▶ Uneasiness about H. ▶ Painful pulsations of H. on attempting to study or write. ▶ Fluttering of H. and oppression in its region, with great desire to walk in the open air. ▶ Pulse rapid; and full and strong; slow; small; small and weak; scarcely perceptible at wrist.

Convulsions of muscles of neck; of nape. ▶ Painful twitchings of muscles of neck. ▶ Painful pulsations in left side of neck. ▶ Sharp pain below left scapula on inspiration. ▶ Drawing pain below scapula on inspiration. ▶ Acute pain in kidney region. ▶ Heaviness and fatigue of lumber muscles.

Paralytic weakness of arms and legs. ▶ Numbness of hands and feet; of hands and arms. ▶ Twitching of arms. ▶ Pain in deltoids; right; left in morning on dressing, amel. rest. ▶ Pulsating pain in left upper arm. ▶ Feeling in upper arm as after a blow. ▶ Jerking pain in arm on attempting to remove the handkerchief from breast pocket. ▶ Twitching of lower. ▶ Weakness of lower. ▶ Paralytic sensations of lower. ▶ Knees give way when walking. ▶ Sudden pain in left knee preventing walking and ceasing suddenly. ▶ Sprained pain in morning; S. feeling compelling him to stop abruptly when walking. ▶ Painful pulsations insoles, agg. resting them against a hard object.

Eczema. ▶ Soreness after neuralgia. ▶ Sensitiveness to touch. ▶ Sensation as if a fly were crawling on chest, not amel. rubbing or scratching. ▶ Itching; over whole body; on face and head, gradually extending over body, with heat.

Sleepiness; with heaviness and gaping; with inability to sleep. ▶ Sleeplessness. ▶ Frequent waking, with the covers thrown off. ▶ Sleep unrefreshing. ▶ Dreams; unpleasant, of dead persons, etc.; pleasant; ridiculous.

Cold skin; and moist; and clammy. ▶ Cold limbs. ▶ Agreeable warmth. ▶ General warmth, with itching, agg. between shoulders. ▶ Heat in head. ▶ Sweat in large beads on forehead.